Award
National Heart, Lung, and Blood Institute 5R01HL156986-05
Angiotensin-(1-7) and Hypothalamic control of blood pressure
Recipient
Pennsylvania State University Hershey Medical Center
Award Amount
$449,939.00
Ceiling
$449,939.00
Awarded
April 11, 2025
Identifier
5R01HL156986-05
NIH research grant awarded to Pennsylvania State University Hershey Medical Center to study the effects of angiotensin-(1-7) on blood pressure regulation in obesity through hypothalamic neural circuits.
Description
This project investigates the role of angiotensin-(1-7) in reducing sympathetic outflow and blood pressure in obesity, focusing on neural circuits in the hypothalamus. It aims to determine if angiotensin-(1-7) provides cardiovascular protection in obesity by engaging brain circuits to reduce sympathetic outflow and blood pressure, exploring neural mechanisms in the hypothalamus, specifically the arcuate nucleus, and assessing the role of GABAergic POMC neurons and cyclic AMP systems in blood pressure regulation.