Award
National Institute of General Medical Sciences 2R01GM145752-05
Trapping reactive intermediates and their application towards catalysis
Recipient
Harvard University, Cambridge, MA, United States
Award Amount
$350,348.00
Ceiling
$350,348.00
Awarded
July 24, 2026
Identifier
2R01GM145752-05
Research project to develop novel metal-ligand complexes for catalysis targeting C–H bond functionalization, with applications in pharmaceuticals and energy.
Description
The project aims to synthesize and characterize novel metal-ligand multiple-bonds mimicking biological monooxygenases, capable of delivering functionalities into C–H bond substrates. It focuses on developing reactive metal-ligand complexes featuring nitrene and oxo functionalities, and examining their reaction chemistry to enable new C–H bond functionalization catalysis.