Award
NIH Reporter #5R35GM137895-07
Elucidating physiology of dormant bacteria to combat antibiotic persistence
Recipient
Harvard Medical School, Boston, MA, United States
Award Amount
$460,371.00
Ceiling
$460,371.00
Awarded
August 25, 2026
Identifier
5R35GM137895-07
Research project funded by NIGMS to study survival mechanisms of dormant bacteria and identify targets for new antibiotics, using advanced scientific techniques.
Description
The project aims to generate fundamental insights into how non-growing bacteria survive and identify vulnerabilities that can be targeted by novel antibiotics. It focuses on mechanisms like plasmolysis, cell envelope permeability, and regulation of cytoplasmic osmotic pressure, using advanced microscopy, mass spectrometry, and mathematical modeling.