National Institute of General Medical Sciences 5R35GM141012-05

Mapping and modeling transcription factor networks

NIH grant awarded to Washington University to develop methods for mapping and modeling transcription factor networks in yeast, aiming to improve understanding of gene regulation and transcriptional responses, with potential applications to human health.

Description

This NIH grant focuses on developing computational and molecular methods to map and model transcription factor networks in yeast, with applications to fungal pathogens and humans. The research aims to optimize methods for determining gene regulation by transcription factors, infer transcription factor activity levels, identify proteins regulating transcription factors, and develop a quantitative model predicting transcriptional responses to perturbations.

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