Award
National Heart, Lung, and Blood Institute 1R01HL178985-01A1
Integrative approach to discover genes that disentangle obesity from cardiometabolic risk in a large multi-ancestry study
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Award Amount
$853,251.00
Ceiling
$853,251.00
Awarded
June 26, 2026
Identifier
1R01HL178985-01A1
A research project funded by the National Heart Lung and Blood Institute to identify genetic factors influencing obesity and cardiometabolic risk using large-scale genomic data and advanced analytic methods.
Description
This project aims to utilize large-scale genomic data and analytic strategies in up to 1.6 million people to identify genes and pathways that contribute to obesity and cardiometabolic risk, focusing on the heterogeneity of obesity and its genetic underpinnings. The study will expand discovery of MHO variants, conduct multi-trait and multi-ancestry GWAS in 1.3 million individuals, and implement multi-omic approaches to prioritize candidate genes. It will also perform exome-wide searches for rare variants in 1.6 million individuals and functionally characterize candidate genes using CRISPRi experiments.