Award
National Institute of Allergy and Infectious Diseases 5R01AI173327-04
Mechanism and Inhibition of Thogotovirus Entry
Recipient
Washington University
Award Amount
$700,837.00
Ceiling
$700,837.00
Awarded
December 08, 2025
Identifier
5R01AI173327-04
NIH grant awarded to Washington University to study the mechanisms and inhibition of Thogotovirus entry, focusing on viral attachment, internalization, and potential therapeutic targets.
Description
This project aims to identify the mechanisms and inhibitors of Thogotovirus entry and class III fusion protein function. The research will characterize monoclonal antibodies against the virus glycoprotein, define the entry pathway, and elucidate host factors involved, particularly focusing on glucosylceramide synthase (UGCG). The study will provide insights into viral attachment, internalization, membrane fusion, and potential therapeutic targets.