# NIH Reporter #1F31HL186594-01

Defining the Roles of mucus and Pseudomonas Aeruginosa EPS in Sensory Neuron Evasion in CF Lungs

**Recipient:** National Heart Lung and Blood Institute (NHLBI), United States

**Award Amount:** $50,114.00
**Ceiling:** $50,114.00

**Awarded:** August 24, 2026

**Identifier:** 1F31HL186594-01

This project aims to elucidate a novel mechanism of sensory neuron evasion by P. aeruginosa in cystic fibrosis lungs, potentially revealing new targets for neuroimmune interactions to enhance bacterial clearance.

### Description

This project investigates the role of mucus and bacterial exopolysaccharides in sensory neuron detection and immune response during P. aeruginosa infection in cystic fibrosis lungs. The research aims to identify mechanisms of sensory neuron evasion by P. aeruginosa to improve bacterial clearance. The project involves use of Scnn1b-Tg mice and sensory neuron ablation with resiniferatoxin.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11385964)