Award
U.S. Department of Veterans Affairs 1I01RD001550-01A1
A systems biology approach to identifying mechanisms underlying enhanced reactogenicity after mRNA-based vaccination
Recipient
Louis Stokes Cleveland VA Medical Center
Awarded
April 08, 2026
Identifier
1I01RD001550-01A1
Research project to understand adverse reactions to mRNA COVID-19 vaccines in veterans using systems biology, focusing on immune response pathways and demographic influences.
Description
This project aims to investigate the mechanisms of reactogenicity (adverse events) following mRNA COVID-19 vaccination using systems biology approaches, particularly in veteran populations. The study will assess local and systemic adverse events, analyze cellular and transcriptomic changes, and model the impact of age and sex on vaccine responses.