Award
National Cancer Institute 3R01CA259037-05S1
Tuning PARP-1 retention and release on DNA breaks
Recipient
University of Pennsylvania
Award Amount
$123,563.00
Ceiling
$123,563.00
Awarded
March 05, 2026
Identifier
3R01CA259037-05S1
NIH grant awarded to University of Pennsylvania to study PARP-1 mechanisms and develop cancer therapy tools, with a focus on structural biology and medicinal chemistry.
Description
This project aims to understand PARP-1 activation, regulation, and inhibition mechanisms, and develop small molecule tools for cancer therapy. It involves structural biology, medicinal chemistry, and in vivo tumor models to advance cancer therapeutics targeting PARP-1.