Award
National Institute of Diabetes and Digestive and Kidney Diseases 5K01DK141969-02
The mechanistic study on irisin-mediated immune response and its role in adipose tissue dynamics
Recipient
Dana-Farber Cancer Institute
Award Amount
$150,722.00
Ceiling
$150,722.00
Awarded
April 27, 2026
Identifier
5K01DK141969-02
NIH grant awarded to Dana-Farber Cancer Institute to study irisin's role in immune response and adipose tissue dynamics, aiming to develop therapeutic targets for metabolic diseases.
Description
This NIH research grant focuses on understanding the molecular mechanisms of irisin's action, particularly its interaction with the IL33-ST2 immune pathway, and its potential to serve as a therapeutic target for metabolic diseases such as obesity and type II diabetes. The project investigates irisin's role in adipose-immune cross talk, downstream immune response pathways, thermogenic regulation, and potential hormone analogs for diabetes treatment.