Award
National Institute of Dental and Craniofacial Research 11370009
An organ on-a-chip model of oral cancer and bone invasion
Recipient
Oregon Health & Science University
Award Amount
$688,490.00
Ceiling
$688,490.00
Awarded
March 30, 2026
Identifier
11370009
Award for developing an organ-on-a-chip model to study oral cancer and bone invasion, funded by the National Institute of Dental and Craniofacial Research, with a focus on biological mechanisms and therapeutic testing.
Description
The project involves developing an organ-on-a-chip model for oral cancer and bone invasion, focusing on head and neck squamous cell carcinoma. It aims to manipulate, characterize, and validate tissue microenvironment variables linked to OSCC-bone invasion, elucidate biological mechanisms, and test therapeutic effects. Validation through clinical sample comparisons is included, aiming to be a high-fidelity model for drug efficacy and safety testing.