NIH Reporter #5U54CA163071-13

The impact of biobehavioral factors and aspirin on ovarian cancer biology

The awarded project investigates how chronic stress and aspirin use affect ovarian cancer progression, focusing on inflammatory and immune mechanisms, aiming to develop preventive and therapeutic strategies.

Description

This project aims to evaluate the hypothesis that distress enhances ovarian cancer progression by promoting inflammatory and immune processes and that aspirin abrogates these effects, using population-based and experimental resources. Growing evidence indicates that the biological response to chronic stress and subsequent distress can promote the progression of epithelial ovarian cancer via prolonged activation of the sympathetic nervous system and sustained norepinephrine release. Downstream consequences of norepinephrine exposure include increased prostaglandin-related inflammation and an immunosuppressive landscape. Conversely, increasing evidence supports the role of aspirin use in ovarian cancer prevention and survival.

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