Award
National Institute of Dental and Craniofacial Research 5R21DE032153-02
Controlled antibiotic delivery vehicle for treatment of aggressive periodontitis
Recipient
LEHIGH UNIVERSITY
Award Amount
$192,046.00
Ceiling
$192,046.00
Awarded
February 29, 2024
Identifier
5R21DE032153-02
This NIH-funded project aims to develop an innovative antibiotic delivery system using liposomes responsive to LtxA toxin to treat aggressive periodontitis in adolescents, potentially improving oral health outcomes.
Description
Development of a liposome-based, LtxA-responsive antibiotic delivery vehicle for periodontal infections targeting Aa infections in adolescents, focusing on targeted release in the presence of pathogenic strains. The research will optimize liposome composition for enhanced LtxA adsorption and disruption, and evaluate the effect on host cell survival in co-culture models. The expected outcome is a novel therapeutic option with significant clinical impact, aligning with the mission of the NIDCR to improve oral health.