Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR080127-05
Mechano signals regulating tendon and ligament homeostasis
Recipient
SCRIPPS RESEARCH INSTITUTE, THE
Award Amount
$384,560.00
Ceiling
$384,560.00
Awarded
July 14, 2026
Identifier
5R01AR080127-05
The award supports research on the mechanosensory molecule Piezo1 to understand its role in tendon and ligament homeostasis and physical performance, with implications for treating musculoskeletal disorders.
Description
This project aims to examine the function of Piezo1, a mechanosensory molecule, to clarify an unexplored critical role of the tendon/ligament in tissue homeostasis and exercise ability. The research will explore Piezo1's role in tendon and ligament physiology, potentially contributing to novel medical strategies for musculoskeletal disorders resulting from tendon/ligament injuries or aging-related degradation.