Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK116868-09
Host integration of commensal and pathogenic bacterial-derived signals
Recipient
Cincinnati Children's Hospital Medical Center
Award Amount
$488,159.00
Ceiling
$488,159.00
Awarded
May 27, 2026
Identifier
5R01DK116868-09
NIH grant awarded to Cincinnati Children's Hospital Medical Center to study how bacterial metabolites regulate intestinal epithelial cells to protect against infection, aiming to improve intestinal immunity.
Description
This NIH grant opportunity focuses on understanding microbial metabolites and their role in intestinal immunity, with potential therapeutic implications for bacterial infections. The project aims to decipher mechanisms that protect against intestinal bacterial infection by investigating microbial signals and their regulation of intestinal epithelial cells using Citrobacter rodentium as a model.