Award
NIH Reporter #5K08AI183990-02
ENHANCEMENT OF CD4CAR T-CELL PERSISTENCE IN VIVO
Recipient
University of Washington, Seattle, WA, United States
Award Amount
$186,408.00
Ceiling
$186,408.00
Awarded
August 11, 2025
Identifier
5K08AI183990-02
The award supports research to improve the persistence and effectiveness of HIV-targeting CAR T cells to achieve long-term viral remission without ART, by overcoming soluble antigen inhibition and enhancing T-cell survival using IL15 cytokine.
Description
This project aims to advance HIV-targeting CAR T cells with enhanced long-term persistence to achieve viral suppression without the need for antiretroviral therapy (ART). The research focuses on overcoming the inhibitory effects of soluble antigen on CD4CAR T-cell function and enhancing T-cell persistence using IL15 cytokine strategies. The project involves gene therapy and adoptive cellular therapies for HIV, validated in a non-human primate model.