Award
National Institute of General Medical Sciences 5F31GM157952-02
Investigating the in vivo regulation of Dynein activity
Recipient
Augusta University
Award Amount
$42,545.00
Ceiling
$42,545.00
Awarded
April 29, 2026
Identifier
5F31GM157952-02
Research project funded by NIGMS to study how Dynein motor protein is activated in vivo by cargo adaptors in Drosophila reproductive tissue, with implications for neurological disorders.
Description
This project seeks to understand the molecular mechanism by which the minus-end directed microtubule motor, Dynein, is activated for motility in vivo by cargo adaptors. The study focuses on Dynein's activation in the female germline of Drosophila melanogaster, testing hypotheses about the roles of cargo adaptors Bicaudal-D (BicD), Hook, and Ninein. The research aims to elucidate mechanisms of Dynein activation relevant to neurological disorders.