Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK131497-05
Mechanisms of HIV persistence in the kidney
Recipient
Duke University
Award Amount
$636,093.00
Ceiling
$636,093.00
Awarded
July 24, 2026
Identifier
5R01DK131497-05
Research project funded to study HIV persistence and reactivation in kidney cells, with implications for HIV cure strategies and renal disease understanding.
Description
This project investigates the mechanisms of HIV persistence and reactivation in the kidney, focusing on renal epithelial cells as potential long-term reservoirs. It aims to analyze samples from HIV+ to HIV+ kidney transplants, assess HIV reactivation following ART interruption, and explore the role of APOL1 kidney disease risk variants.