Award
NIH Reporter #5R01AI183392-03
Adipocytes and inflammation in the cutaneous leishmaniasis outcome
Recipient
FEDERAL UNIVERSITY OF BAHIA
Award Amount
$120,226.00
Ceiling
$120,226.00
Awarded
July 28, 2026
Identifier
5R01AI183392-03
Research project studying how adipose tissue and obesity affect cutaneous leishmaniasis severity, focusing on inflammatory responses and macrophage reprogramming by lipids.
Description
This project investigates the influence of adipose tissue and obesity on the severity of cutaneous leishmaniasis. It explores the role of adipokines, lipid profiles, and leucocyte infiltration in adipose tissue in inflammatory response-mediated tissue damage and disease severity. The study also examines how lipids can reprogram macrophages towards a wound healing phenotype, aiming to understand disease outcomes and therapeutic failures, particularly in obese patients.