Award
National Institute of Neurological Disorders and Stroke 5R01NS128412-04
Contribution of IL6 trans signaling in older females after ischemic stroke
Recipient
University of Texas Health Science Center Houston
Award Amount
$622,827.00
Ceiling
$622,827.00
Awarded
March 23, 2026
Identifier
5R01NS128412-04
NIH awarded a research grant to the University of Texas Health Science Center Houston to study IL6 trans-signaling in older females after ischemic stroke, aiming to improve recovery outcomes through sex-specific therapies.
Description
This NIH research grant focuses on understanding the role of interleukin-6 trans-signaling in older females after ischemic stroke to develop effective therapies for improving long-term recovery in older women. The study investigates sex-dependent molecular mechanisms regulating IL6/IL6R signaling post-stroke, particularly in microglia, and aims to inform sex-specific therapeutic strategies for elderly stroke patients.