Award
National Institute of Neurological Disorders and Stroke 5K00NS130872-04
Inhibition of MMP-9 Activity Impairs Working Memory in Zebrafish Through Changes in Overall Hippocampal Excitation
Recipient
Vanderbilt University Medical Center, Nashville, TN, United States
Award Amount
$96,244.00
Ceiling
$96,244.00
Awarded
May 19, 2026
Identifier
5K00NS130872-04
Research project funded by the National Institute of Neurological Disorders and Stroke to study the role of MMP-9 in memory impairment and vascular contributions to Alzheimer's disease using advanced techniques.
Description
This NIH-funded research project investigates how vascular changes, through increased Matrix Metalloproteinase-9 (MMP-9) activity, affect neuronal activity in the retrosplenial cortex, a region crucial for associative learning and memory, aiming to identify therapeutic targets to prevent or reduce memory deficits related to Alzheimer's disease and related dementias (ADRDs).