Award
NIH Reporter #3R01AG075927-04S1
Whole Genome Sequencing and Admixture Analyses of Neuropathologic Traits in Diverse Cohorts in USA and Brazil
Recipient
RUSH UNIVERSITY MEDICAL CENTER
Award Amount
$1,226,060.00
Ceiling
$1,226,060.00
Awarded
August 11, 2026
Identifier
3R01AG075927-04S1
This NIH-funded project aims to perform whole genome sequencing and admixture analyses on diverse cohorts in the USA and Brazil to study neuropathologic traits related to Alzheimer’s disease and related dementias, focusing on multiple genetic analyses and diverse ancestries.
Description
The project involves whole genome sequencing (WGS) on diverse cohorts in the USA and Brazil to identify molecular drivers of Alzheimer’s disease and related dementias (AD/ADRD). It includes generating WGS data, admixture mapping, telomere length analysis, and mitochondrial DNA association studies, with collaboration from the Alzheimer’s Disease Sequencing Project (ADSP). The research emphasizes populations of African, European, and Native Brazilian ancestry.