Award
National Institute of General Medical Sciences 5R01GM146803-05
A new paradigm of general transcription factor TFIIB functionality in termination and promoter directionality
Recipient
Wayne State University
Award Amount
$307,175.00
Ceiling
$307,175.00
Awarded
May 20, 2026
Identifier
5R01GM146803-05
Research grant awarded to Wayne State University to study the multifunctional role of transcription factor TFIIB in gene regulation, including termination and promoter directionality.
Description
This research grant focuses on elucidating the role of the general transcription factor TFIIB in transcriptional regulation, specifically its involvement in termination and promoter directionality of genes by recruiting termination factors. The project includes genome-wide analysis, molecular basis elucidation, and characterization of the holo-TFIIB complex.