Award
National Cancer Institute 1K99CA312797-01
Investigating the bidirectional tumor-host crosstalk in cachexia and pancreatic ductal adenocarcinoma
Recipient
University of Massachusetts Medical School Worcester, MA
Award Amount
$142,251.00
Ceiling
$142,251.00
Awarded
May 13, 2026
Identifier
1K99CA312797-01
NIH awarded a grant to investigate the molecular mechanisms of cachexia in pancreatic cancer, focusing on tumor-host interactions and the role of obesity in disease progression.
Description
This NIH grant project aims to study cachexia onset in chronic pancreatitis models to understand its molecular drivers, focusing on tumor-derived PTHrP and mediators of cachexia at metabolic, transcriptomic, and proteomic levels, as well as how obesity influences pancreatic ductal adenocarcinoma development through adipose signaling.