National Heart, Lung, and Blood Institute 11174288

Mechanisms of Cell-Free Hemoglobin-Mediated Injury to the Pulmonary Endothelial Glycocalyx in Sepsis

Research project funded by NIH to study how cell-free hemoglobin injures the pulmonary endothelial glycocalyx in sepsis, aiming to find therapeutic targets for sepsis-associated lung injury.

Description

The project focuses on understanding the molecular mechanisms through which cell-free hemoglobin damages the endothelial glycocalyx in sepsis. The research involves mechanistic studies in cultured human lung microvascular endothelial cells and murine models. The project aims to identify targets for therapeutic development to treat sepsis-associated lung injury. The award is part of NIH funding under PA-21-049. The project duration is from September 1, 2023, to August 31, 2027. The project emphasizes developing skills in critical thinking and communication for the investigator.

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