Award
National Institute of General Medical Sciences 1R01GM159656-01A1
A novel role for LONP1 in connecting mitochondrial proteostasis with nuclear epigenetics
Recipient
Baylor College of Medicine
Award Amount
$348,800.00
Ceiling
$348,800.00
Awarded
July 24, 2026
Identifier
1R01GM159656-01A1
This NIH-funded research project explores how the mitochondrial enzyme LONP1 regulates nuclear gene activity through metabolic signals, with implications for stem cell regeneration, cancer progression, aging, and related disorders.
Description
Investigates the role of mitochondrial protease LONP1 in linking organelle proteostasis with nuclear transcription, focusing on metabolites from the TCA cycle and their impact on epigenetic regulation and gene expression.