Award
National Heart, Lung, and Blood Institute 5R01HL149743-04
Role of GM-CSF in Alveolar Macrophage Self-Renewal
Recipient
Cincinnati Children's Hospital Medical Center
Award Amount
$529,995.00
Ceiling
$529,995.00
Awarded
November 15, 2024
Identifier
5R01HL149743-04
NIH grant awarded to study the role of GM-CSF in alveolar macrophage self-renewal, focusing on mitochondrial metabolism and cellular mechanisms to inform lung disease therapies.
Description
This project aims to elucidate the mechanisms by which GM-CSF regulates alveolar macrophage self-renewal, challenging existing paradigms and potentially informing new therapeutic strategies for lung diseases. The research will explore how GM-CSF regulation of mitochondrial homeostasis controls alveolar macrophage self-renewal, with implications for therapies for lung diseases such as hereditary pulmonary alveolar proteinosis and pulmonary macrophage transplantation therapy.