NIH Reporter #5R35GM126966-09

Mechanisms of Circadian Clock Control of mRNA Translation

This NIH-funded project studies the circadian clock's role in controlling protein synthesis accuracy and diversity, aiming to understand its impact on health and drug metabolism.

Description

Circadian clocks regulate daily rhythms in mRNA levels and protein production to control cell physiology, and defects in the clock are associated with sleep disorders, metabolic syndrome, cancer, and heart disease. This project investigates how the circadian clock regulates the levels and accuracy of protein synthesis, potentially providing insights into new treatments for clock-associated diseases and improving drug treatment timing.

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