# NIH Reporter #1R01MH141441-01A1

Development of genetically encoded sensors and high-speed FLIM for in vivo quantitative multiplexed voltage imaging

**Recipient:** Brown University

**Award Amount:** $889,894.00
**Ceiling:** $889,894.00

**Awarded:** September 08, 2026

**Identifier:** 1R01MH141441-01A1

Award to Brown University by the National Institute of Mental Health to develop genetically encoded voltage sensors and a high-speed fluorescence lifetime imaging system for multiplexed in vivo brain activity imaging.

### Description

This project aims to develop and validate new biosensors for quantitative and multiplexed imaging of electrical activity in the brain. By combining these sensors with a novel high-speed two-photon fluorescence lifetime microscopy system, we will enable precise measurements of electrical activity across multiple cell types in behaving animals, advancing understanding of brain computations and their disruption in neurodevelopmental and psychiatric disorders.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11368403)