Award
National Cancer Institute 5UG3CA290468-02
Preclinical studies for the immunoprevention of multiple myeloma
Recipient
Mayo Clinic Arizona, Scottsdale, AZ, United States
Award Amount
$704,622.00
Ceiling
$704,622.00
Awarded
June 08, 2026
Identifier
5UG3CA290468-02
Award for preclinical research on immunoprevention of multiple myeloma using mouse models to study immunomodulatory agents and the role of the microbiome and inflammation.
Description
This project aims to develop faithful pre-clinical mouse models to study immunoprevention strategies, including immunomodulatory agents like IMiDs, NSAIDs, NLRP3 inhibitors, and IL18 antibodies. The research will explore the role of the gut microbiome and systemic inflammation in disease progression, providing a basis for clinical trials.