Award
National Institute of Allergy and Infectious Diseases 3R01AI175177-03S1
C. albicans-intrinsic mechanisms defining gut colonization
Recipient
Brown University
Award Amount
$79,748.00
Ceiling
$79,748.00
Awarded
July 01, 2026
Identifier
3R01AI175177-03S1
Research project funded by NIAID to study Candida albicans gut colonization mechanisms, focusing on fungal growth, morphology, toxin Candidalysin, and interactions with bacterial microbiota.
Description
The research aims to understand the mechanisms by which Candida albicans colonizes the gastrointestinal (GI) tract, focusing on its growth, morphology, and interaction with bacterial microbiota. It investigates the role of the toxin Candidalysin in fungal fitness and competition within the GI niche, using murine models with native or defined bacterial populations. The study seeks to identify factors influencing gut colonization and how C. albicans operates as a human pathobiont.