Award
NIH Reporter #1R01AI201499-01
IFN-dependent and IFN-independent pathways in SLE
Recipient
Johns Hopkins University
Award Amount
$748,333.00
Ceiling
$748,333.00
Awarded
August 14, 2026
Identifier
1R01AI201499-01
Research project to study interferon-dependent and independent pathways in systemic lupus erythematosus (SLE) to classify patients and develop targeted treatments.
Description
The project aims to examine the mechanisms underlying systemic lupus erythematosus (SLE) that are dependent and independent of interferons. It seeks to classify SLE patients into at least three disease subsets based on IFN levels and signatures, providing insights into disease heterogeneity and response variability in clinical trials. The long-term goal is to develop precise mechanism-guided preventive and therapeutic interventions for SLE.