Award
National Institute of General Medical Sciences 5R35GM156386-02
Understanding general principles in receptor tyrosine kinase signaling through structural and functional studies
Recipient
UT Southwestern Medical Center, Dallas, TX
Award Amount
$574,000.00
Ceiling
$574,000.00
Awarded
February 09, 2026
Identifier
5R35GM156386-02
This NIH-funded project aims to elucidate the mechanisms of RTK activation and regulation through structural and functional studies, combining cryo-EM, biochemistry, and cell biology to advance therapeutic development.
Description
Research project to explore the structures and functions of ligand-bound full-length receptor tyrosine kinases (RTKs) in both dimeric and higher-order conformations using cryo-EM, biochemistry, and cell biology to understand conformational changes and signaling specificity, potentially leading to new therapeutics.