Award
National Institute of Allergy and Infectious Diseases 5R01AI168114-05
Accelerating Malaria Vaccines with a Custom Preclinical Humanized Mouse Model Platform
Recipient
Massachusetts General Hospital
Award Amount
$697,695.00
Ceiling
$697,695.00
Awarded
February 12, 2026
Identifier
5R01AI168114-05
The award funds research to accelerate malaria vaccine development using genetically engineered humanized mouse models to validate vaccine candidates targeting Plasmodium falciparum.
Description
This project aims to expedite preclinical testing of malaria vaccines by creating human-like genetically engineered mouse models. The models will be used to validate potential vaccine candidates, focusing on the circumsporozoite protein (CSP) of Plasmodium falciparum. The research involves developing mouse models expressing human B cell receptors, immunization with junctional epitope peptides, and exploring immunogenicity of CSP subdomains.