Award
National Institute of General Medical Sciences 5R35GM133802-07
Cellular mechanisms of peptidergic signaling
Recipient
University of California, San Diego
Award Amount
$438,859.00
Ceiling
$438,859.00
Awarded
February 18, 2026
Identifier
5R35GM133802-07
Research grant to study cellular mechanisms of peptide secretion to identify new drug targets for metabolic, neurological, and neurodegenerative diseases.
Description
The project aims to elucidate cellular mechanisms that govern peptide secretion in the nervous and endocrine systems, which are compromised in various diseases such as diabetes, thyroid disorders, sleep disorders, eating disorders, and depression. The research will explore diverse mechanisms of peptide release, challenging the existing calcium-centric paradigm, and will develop assays for monitoring neuropeptide actions. The ultimate goal is to identify new drug targets for metabolic, neurological, and neurodegenerative diseases.