Award
National Institute of Mental Health 5R01MH136102-03
Multisystem Stress Response Biotypes: Deriving Novel Physiological and Neural Risk Factors for Anhedonia in Adolescence
Recipient
University of North Carolina at Chapel Hill
Award Amount
$748,732.00
Ceiling
$748,732.00
Awarded
June 23, 2026
Identifier
5R01MH136102-03
This NIH-funded project studies how biological acute stress response mechanisms influence anhedonia severity and trajectory in adolescents, using multimodal approaches including fMRI and physiological assessments to develop targeted interventions.
Description
The project aims to examine the individual and interactive roles of physiological and neural mechanisms associated with acute stress experiences to the severity and maturational trajectory of anhedonia in adolescence, potentially informing novel prevention and intervention strategies. It involves identifying multisystem stress response biotypes and determining characteristics of stress profiles that predict the severity and trajectory of anhedonia in adolescents aged 13-15 years.