Award
National Institute of General Medical Sciences 5R35GM154813-03
Molecular mechanisms of Eph receptor signaling
Recipient
Ohio State University, Columbus, OH
Award Amount
$385,345.00
Ceiling
$385,345.00
Awarded
June 19, 2026
Identifier
5R35GM154813-03
Research project funded by NIGMS to study Eph receptor signaling mechanisms using advanced molecular biology techniques, with potential applications in neurodegeneration and cancer.
Description
This project aims to dissect receptor protein oligomerization (clustering) in cell-cell interactions, focusing on Eph receptors in human cells. The research will utilize optogenetics, genome editing, single-molecule fluorescence imaging, and high-throughput sequencing to understand Eph receptor biology and oligomeric transitions, with implications for health and disease.