Award
NIH Reporter #5R00HL148523-05
Role of epicardial adiposity as a local mediator of VT/VF dynamics in donor human hearts
Recipient
State University of New York at Buffalo, Amherst, NY
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
February 24, 2025
Identifier
5R00HL148523-05
Research project funded by the National Heart Lung and Blood Institute to study how obesity-induced epicardial adiposity affects ventricular arrhythmias in human hearts, aiming to develop predictive and treatment markers for VT/VF.
Description
This project aims to use a multimodal and multiscale approach to characterize ventricular tachyarrhythmias (VT/VF) in donor human hearts associated with sustained obesity, investigating the role of epicardial adiposity in promoting VT/VF via paracrine signaling and generating arrhythmogenic triggers. The research involves bioinformatics, adipocyte biology, and cardiac electrophysiology, with the goal of developing new markers for predicting and treating VT/VF.