Award
National Cancer Institute 4R01CA285684-03
A novel role for EZH2 in PARP regulation and PARPi-resistance in prostate cancer
Recipient
Northwestern University
Award Amount
$1,701,594.00
Ceiling
$1,701,594.00
Awarded
June 30, 2026
Identifier
4R01CA285684-03
Research grant awarded to study the role of EZH2 in DNA repair and resistance to PARP inhibitors in prostate cancer, aiming to develop new targeted therapies.
Description
This project aims to develop effective treatments and address mechanisms of therapeutic resistance for men with metastatic prostate cancer by investigating how EZH2 methylates its substrate PARP1 and how this methylation affects DNA damage repair and transcription regulation, as well as exploring EZH2's role in PARP inhibitor resistance to identify new therapeutic targets.