Award
NIH Reporter #2R01DC004729-26A1
Analysis of Chemosensory Receptor Genes
Recipient
Yale University
Award Amount
$461,066.00
Ceiling
$461,066.00
Awarded
August 14, 2026
Identifier
2R01DC004729-26A1
Research project funded by the National Institute on Deafness and Other Communication Disorders to study chemosensory receptor genes in Drosophila melanogaster, aiming to understand chemical signal encoding and develop insect control methods.
Description
The project uses the model system Drosophila melanogaster to analyze chemosensory receptors, neuronal responses, and behavior. It focuses on the molecular basis of species recognition and mate detection, analyzing ionotropic receptor genes Ir52a, Ir52b, Ir52c, Ir52d, and Ir52e. The project involves testing receptor responses to pheromones across species, creating hybrid flies with gene replacements, and understanding how chemical signals are encoded and translated into behavior. This research aims to develop new methods for insect control and disease prevention.