Award
National Institute of Allergy and Infectious Diseases 1R01AI197393-01
Determinants of viral assembly and infectivity within the Ebola virus VP24 protein
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY, USA
Award Amount
$843,182.00
Ceiling
$843,182.00
Awarded
April 17, 2026
Identifier
1R01AI197393-01
NIH funded project to study Ebola virus VP24 protein's role in viral assembly and infectivity, focusing on nuclear export signals and interactions affecting virus production.
Description
This project aims to understand the mechanisms by which Ebola virus (EBOV) assembles and releases infectious particles, focusing on the role of the VP24 protein. The study will investigate nucleocytoplasmic trafficking of VP24, its role in viral genome packaging, and its interactions with cellular components such as the Wave regulatory complex (WRC). The research will elucidate how VP24's nuclear export signal (NES) sequences and interactions with importin α (IMPA) influence virus production and infectivity.