Award
NIH Reporter #5R35GM149337-04
A translational approach to predicting small molecule drug permeation through microneedle-treated skin
Recipient
University of Iowa, Iowa City, IA, United States
Award Amount
$399,104.00
Ceiling
$399,104.00
Awarded
July 15, 2026
Identifier
5R35GM149337-04
The project aims to improve drug delivery by studying how small molecule drugs permeate through microneedle-treated skin, using both laboratory and clinical studies to understand key factors affecting absorption.
Description
This project investigates how chemical properties of drug compounds affect drug absorption through microneedle-treated skin, using in vitro permeation tests and in vivo pharmacokinetics in animals and humans, focusing on properties like ionization, logP, and pKa, with a goal to improve drug delivery methods.