Award
National Institute of Dental and Craniofacial Research 5R01DE031413-05
Mechanism of LSD1 Function and Its Therapeutic Application for Progressive Oral Malignancy
Recipient
Boston University Medical Campus, Boston, MA, United States
Award Amount
$411,444.00
Ceiling
$411,444.00
Awarded
January 29, 2026
Identifier
5R01DE031413-05
The award supports research on the mechanism of LSD1 in oral cancer progression and the development of therapeutic applications using LSD1 inhibitors to prevent and treat progressive oral malignancy.
Description
This project investigates the role of LSD1 in oral cancer progression and explores targeted epigenetic therapies, including LSD1 inhibitors, in preclinical models. The study aims to determine how LSD1 reprograms oral tissue to invasive phenotype and its role in immune resistance, with potential applications in human and veterinary medicine.