Award
National Institute of Allergy and Infectious Diseases 5R21AI185853-02
Structure and functions of a bacterial Type IV effector complex
Recipient
University of Vermont & St. College
Award Amount
$179,155.00
Ceiling
$179,155.00
Awarded
April 01, 2025
Identifier
5R21AI185853-02
NIH awarded a research grant to the University of Vermont & St. College to study the structure and functions of a bacterial Type IV effector complex from Brucella abortus, focusing on how effector proteins coordinate during infection.
Description
This NIH research grant supports a project to characterize the structure, assembly, and functions of a unique multi-effector platform formed by three effector proteins injected by the bacterial pathogen Brucella abortus into host cells. The project aims to understand how these effector proteins coordinate their functions during the Brucella intracellular cycle using structural biology, biochemistry, and microbiology approaches.