Award
National Heart, Lung, and Blood Institute 5R01HL163081-05
Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study
Recipient
University of Alabama at Birmingham
Award Amount
$709,272.00
Ceiling
$709,272.00
Awarded
June 19, 2026
Identifier
5R01HL163081-05
This NIH grant supports research on genetic and molecular mechanisms influencing cardiometabolic health, focusing on ANP and miR-425 responses to metabolic challenges, aiming to develop RNA-based therapeutics.
Description
The project investigates the role of genetic variation in atrial natriuretic peptide (ANP) hormone regulation and its impact on cardiometabolic health. It focuses on the ANP gene variant rs5068 and microRNA-425 (miR-425), exploring their influence on glucose utilization, energy homeostasis, and blood pressure regulation. The study aims to assess the response of ANP and miR-425 to metabolic challenges such as glucose and exercise, and how these responses differ by genotype.