Award
NIH Reporter #5R35ES030435-07
Early Warning Systems for Childhood and Adult Disorders
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Award Amount
$902,920.00
Ceiling
$902,920.00
Awarded
March 31, 2026
Identifier
5R35ES030435-07
This award funds a project to develop early warning systems for childhood and adult disorders by analyzing biochemical rhythmicity during development to predict and prevent diseases before clinical signs appear.
Description
The project proposes a new paradigm to detect disease years before current clinical and biochemical tests, potentially allowing prediction and prevention of diseases decades before clinical signs. It aims to develop technology analyzing dynamic rhythmicity of key biochemical pathways during fetal development and childhood to detect deviations from homeostasis that could prognosticate later-life disease onset, and to establish a new framework for understanding development as interconnected rhythmic processes embedded within the growth trajectory.