Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR081792-03
CD8 T cell derived Granzyme K activates complement that drives synovial fibroblast inflammation
Recipient
Brigham and Women's Hospital, Boston, MA, United States
Award Amount
$347,191.00
Ceiling
$347,191.00
Awarded
August 15, 2025
Identifier
5R01AR081792-03
NIH funded research project investigating the role of CD8 T cell derived Granzyme K in activating the complement pathway that causes inflammation and joint damage in rheumatoid arthritis, aiming to identify new drug targets.
Description
This project studies how a type of white blood cell (CD8 T cell) and a protein called granzyme activate an inflammatory pathway (the complement pathway) which drives inflammation and joint damage. The research aims to define this new pathway to reveal new targets for drug development to treat rheumatoid arthritis (RA).