Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR078914-05
Mechanisms of bone fragility in Autosomal Dominant Osteopetrosis type II: from human to mouse and back
Recipient
Brigham and Women's Hospital
Award Amount
$251,684.00
Ceiling
$251,684.00
Awarded
July 07, 2026
Identifier
5R01AR078914-05
This NIH-funded project investigates the mechanisms of bone fragility in Autosomal Dominant Osteopetrosis type II by studying osteoclast-osteoblast communication using human and mouse models, aiming to develop new osteoporosis treatments.
Description
The project aims to determine the cell-type specific mechanism of coupling and identify molecular candidates expressed by these cell types using human and mouse models of autosomal dominant osteopetrosis type II (ADOII). ADOII is characterized by high skeletal bone mass and increased fragility, resulting from pathologic coupling. The studies could be critical in developing new treatments for osteoporosis, which affects 54 million elderly Americans.