Award
National Institute of Allergy and Infectious Diseases 5R01AI174646-05
Structural characterization of MCE transport systems from Mycobacterium tuberculosis
Recipient
Johns Hopkins University
Award Amount
$748,237.00
Ceiling
$748,237.00
Awarded
January 28, 2026
Identifier
5R01AI174646-05
Johns Hopkins University received a grant from the National Institute of Allergy and Infectious Diseases to study the structure and function of MCE transport systems in Mycobacterium tuberculosis, aiming to understand their role in bacterial virulence and aid antibiotic development.
Description
This project aims to biochemically and structurally characterize MCE transport systems from Mycobacterium tuberculosis and Mycobacterium smegmatis using cryo-EM, mass spectrometry, and functional assays to understand their structure, function, and role in virulence. The study focuses on protein-based systems that facilitate the transport of nutrients across the cell envelope, which may aid in the design of new antibiotics to treat tuberculosis.