Award
NIH Reporter #5P20GM152335-03
Insulin Misfolding Dynamics and Insulin Signaling Dysfunction
Recipient
MC LAUGHLIN RESEARCH INSTITUTE, GREAT FALLS, MT, UNITED STATES
Award Amount
$317,633.00
Ceiling
$317,633.00
Awarded
April 21, 2026
Identifier
5P20GM152335-03
Research project investigating insulin misfolding and its impact on insulin signaling dysfunction related to type 2 diabetes mellitus, using novel RTQuIC assay methods, with a focus on rural health implications in Montana.
Description
The project focuses on understanding insulin misfolding and its role in diabetes, using innovative RTQuIC method. It aims to examine the state and structure of insulin protein and its role in glucose metabolism pathway, including insulin fibrillization and insulin resistance in preclinical and animal models. The work is significant for rural health research, especially in Montana.